Stem Cells as a Viable Therapeutic for Cystic fibrosis


For stem cell therapy to serve as a viable therapeutic for CF the use of heterologous or gene corrected autologous stem cells which are capable of infusing back into the CF airways and perform the desired role of Chloride secretion would be required. A recent study in experimental animal model for CF has reported the usefulness of MSC as an attractive therapeutic in murine model of CF lung infection and inflammation. In this model, MSCs were shown to improve gross lung pathology and decreased the cellular recruitment into the lung, furthermore MSCs shifted the pulmonary cell predominance from neutrophils to an evenly distributed predominance of macrophages and neutrophils, thus promoting the resolution of infection in CF lung, since a predominately neutrophilic inflammation observed in CF airways is responsible for inflicting a tremendous tissue damage and an even distribution of macrophages would insure a better response to the infection through cell mediated immunity.

For stem cell therapy to function a viable therapeutic for CF the use of heterologous or sequence corrected autologous stem cells that are capable of infusing back to the CF airways and perform the specified role of Chloride secretion would be required. A recent study in experimental animal model for CF has reported the quality of MSC as an alluring therapeutic in murine model of CF lung infection and inflammation. In this model, MSCs were shown to improve gross lung pathology and attenuated the cellular enlisting into the respiratory organ, what is more MSCs shifted the pneumonic cell predominance from neutrophils to AN equally distributed predominance of macrophages and neutrophils, so promoting the resolution of infection in CF respiratory organ, since a predominately neutrophilic inflammation determined in CF airways is answerable for inflicting an incredible tissue harm and an excellent distribution of macrophages would insure an improved response to the infection through cell mediate immunity.

To know more about this evolving topic let us join the upcoming huge conference i.e International conference on Cystic Fibrosis which is going to be held during September 20-21, 2018 at Dubai, UAE which will be a definitively informative platform for all, who are going to attend the conference.

 References: Voynow JA, Fischer BM, Zheng S. Proteases and cystic fibrosis. Int J Biochem Cell Biol. 2008;40(6–7):1238–1245.

Visit:https://cysticfibrosis.conferenceseries.com/



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